中译文一种新的甲状旁腺腺瘤定位技术

本文发表于《SurgicalInnovation》年6月

作者：赵文新等

单位：福建医院

Abstract摘要

Objective.

Thestudyaimstoevaluatetheclinicfeasibilityofrapidparathyroidhormone(PTH)detectionandnano-carbontechnologyinpreoperativediagnosisandlocalizationofparathyroidadenoma.

目的本研究旨在评估甲状旁腺激素（PTH）快速检测和纳米炭技术结合在甲状旁腺腺瘤术前诊断和定位中的临床可行性。

Methods.

Withtheguidanceofultrasound,theoperatorperformedtheparathyroidpunctureandtestedthePTHvaluebyusingaPTHtestkit,andtheninjectednano-carbonintoparathyroidadenomaasamarkertoobservewhethertheparathyroidadenomawasstainedblackduringthefinaloperation.Meanwhile,apartofexcisedspecimenwasmadeintohomogenateanddetectedrapidlyagainbyusingthePTHtestkit.Theremainingwasconfirmedbyintraoperativefrozenpathologicalexamination.

方法在超声引导下，操作者进行甲状旁腺穿刺，并使用PTH检测试剂盒检测PTH值，然后将纳米炭注入甲状旁腺腺瘤作为标志物，观察甲状旁腺腺瘤在最终手术过程中是否染成黑色。同时，将切下的标本的一部分制成匀浆，通过使用PTH检测试剂盒再次快速检测。其余由术中冰冻病理检查证实。

Result.

Thesensitivity(12/12)ofpreoperativediagnosiswassignificantlyhigherthanthatofultrasound(6/12),magneticresonanceimaging(7/12),andMIBI(9/12).Duringtheoperation,wefoundthattheinnerpartoftheparathyroidadenomawasstainedblack,andthePTHvalueofthespecimenhomogenateconfirmedasparathyroidadenomawasmorethanpg/mL.

结果术前诊断的灵敏度（12/12）显著高于超声波（6/12）、磁共振成像（7/12）和MIBI（9/12）。手术过程中，我们发现甲状旁腺腺瘤的内部染成黑色，标本匀浆的甲状旁腺腺瘤的PTH值超过pg/mL。

Conclusion.

Thisnoveltechnology,asaverypositivemethodforlocalizationofparathyroidadenoma,playsanimportantroleinguaranteeingthesurgicalreliabilityofparathyroidadenomawithhelpofnano-carbontechnology.

结论这项新技术，作为甲状旁腺腺瘤定位是一种非常积极的方法，在利用纳米炭技术保证甲状旁腺腺瘤的手术可靠性方面发挥着重要作用。

Keywords关键词

ultrasound-guidedfineneedleaspiration,parathyroidhormone,PTHdetection,parathyroidadenoma,nano-carbon,preoperativelocalization

超声引导下细针穿刺，甲状旁腺激素，PTH检测，甲状旁腺腺瘤，纳米炭，术前定位

Introduction概述

Primaryhyperparathyroidismisarareendocrinedisorderdiagnosedmainlyonthebasisoftheserumparathyroidhormone(PTH)andcalciumlevels.Itischaracterizedbyconstipation,psychiatricdisturbances,fatigue,bonepain,andrenalstonesforthereasonsofhypercalcemiaandseriousbonedestruction.Parathyroidadenoma(PA)includingsolitaryandmultipleonesisthemajorcauseforprimaryhyperparathyroidism.ThedefinitetreatmentofPAissurgicalresectionbasedonpreoperativeaccuratelocalization.

原发性甲状旁腺功能亢进是主要根据血清甲状旁腺激素（PTH）和钙水平诊断的罕见内分泌紊乱。它以便秘、精神紊乱、疲劳、骨痛和肾结石为特征，原因是高钙血症和严重的骨质破坏。甲状旁腺腺瘤（PA）（包括单发和多发）是导致原发性甲状旁腺功能亢进的主要原因。PA的确切治疗是基于术前准确定位的手术切除。

NowvariousfunctionalandanatomicalimagingmodalitieshaveevolvedforpreoperativelocalizationofPA.1Themost







































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